3B. The cell attached patch clamp experiment described above was repeated with c

Question

3B. The cell attached patch clamp experiment described above was repeated with current recordings made from a single voltage-gate K' channel when the membrane was first clamped to a hyperpolarized potential and then clamped to a depolarized potential for 40msec. The current recordings were repeated during seven individual trials. EE -50 0 10 20 30 40 Time (ms) In your answer, address the following: (1) What do the current recordings say about the probability of VGPC opening at depolarized membrane potentials? (2) What observations can be made regarding the "open time" of VGPCs while the membrane is depolarized? (3) How does the structure of the VGPC protein influence the pattern and shape of VGPC activation. Use the space provided below (5 pts) Open2pA Closed 0 10 20 30 40 Time (ms)

Explanation / Answer

voltage gated potassium channels all channels which are open when the change in voltage occurs.

they are specific for the voltage means a particular voltage they are open and then after they will close.

here we can see that the voltage gated potassium channels are open at particular voltage and then after they will close.

1. here we can see that depolarismzation of cell does not affect the opening of voltage gated potassium channels.

These channels opens up when the cell reaches a particular potential of voltage. these range of voltage enhances the opening of voltage gated potassium channels. According to this graph points gave the idea that depolarization leads to closing of voltage gated general for a very short time then again these channels were open. The closing of the channel is also mediated by voltage change.

2. The open time of the channel is considered as the time period when the voltage gated channels are open. and obviously they are open till the period when the required voltage is presented to voltage gated channels. As the voltage gated channels does not able to fulfill the voltage requirement that will close. the maintenance of voltage is done by the ions either positive or negative.

3. voltage gated potassium channels are composed of proteins. the proteins have secondary tertiary and quaternary structures which are responsible for occupying a particular shape and structure. In the protein structure amino acids are present which have various different side chains. the side Chains of the amino acid can be hydrophobic or hydrophilic and can be positive or negatively charged. So we can say that amino acids are sensitive for the change of voltage: the change of voltage leads to changes in the amino acid interactions and this interaction leads to change and the structure of voltage gated potassium channel.

These changes in the structure of voltage gated potassium channels are considered as opening and closing of channels.

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