A Gram-positive bacteriall strain is simultaneously treated with two different a

Question

A Gram-positive bacteriall strain is simultaneously treated with two different antimicrobials: Drug A, which targets a protein involved in cell wall synthesis, and Drug B, which targets ribosomes involved in translation. The bacteria continues to grow during the course of treatment, indicating resistance to both antimicrobials. what are all the possible resistance mechanisms this bacteria strain could have?

check all that apply

a) drug inactivation

b) altered drug target

c) efflux pumps

d) decreased permeability

Explanation / Answer

Antibiotic that target cell wall synthesis must be deactivated (cleaved) as they act at cell wall itself while antibiotics that target translation machinery could simply be overridden by decreased permeability. So these two are must have for the bacteria. Efflux pump could also help fight ribosome attacking antimicrobial. Altered drug targets largely exist for antimicrobials targeting DNA gyrase, or polymerase

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