Multiple endocrine neoplasia 1 (MEN 1) is an autosomal dominant disorder charact

Question

Multiple endocrine neoplasia 1 (MEN 1) is an autosomal dominant disorder characterized by parathyroid hyperplasia and pancreatic islet-cell and pituitary adenomas. Two geneticists constructed the following pedigree chart of a family afflicted with the disease. 2 2 3 2 3 5 Explain how is it possible for ll-1 and II-2 individuals to have two out of four affected children despite the fact that both were perfectly healthy and never showed any sign of the disease. Select one a. Individual II-1 has low expressivity Ob. The inheritance pattern is incomplete dominance. O c. The disease is not 100% penetrant. O d. Individual 11-1 must be a carrier

Explanation / Answer

d- The individual -II-1 is a carrier of the disease. His mother was affected by the disease but since he has only 1 X chromosome, he became a carrier of the disease. This is the reason two of his children has it.

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