Examine the structure of the human growth hormone in complex with its receptor (

Question

Examine the structure of the human growth hormone in complex with its receptor (PDB ID = 3HHR) using the Structure Viewer at rcsb.org. Toggle between Coloring by Chain and by Rainbow to answer the questions below.

Recall that the human growth hormone is a four-helix bundle.

How many receptor chains does a single hormone bind?

If a domain is an independently folding unit, how many domains does each receptor chain appear to contain?

Would you classify these receptor domains as beta, alpha + beta, or alpha/beta?

Do the beta-strands of the receptor domains form sheets, barrels, or sandwiches?

Explanation / Answer

One molecule of growth hormone binds to two receptor chains.

There are two domains that provide residues which participate in hGH binding.

The domains are classified alpha + beta

The domains are similar to immunoglobulin domains. Hence, they form barrel like structure or two -pleated sheets form a sandwich-like structure

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