Biomedical Engineering-Drug Delivery 1-4 Multiple Choice:There might be multiple

Question

Biomedical Engineering-Drug Delivery 1-4 Multiple Choice:There might be multiple answers that are correct. Please list all that are correct 1. Below are the advantages of poly (ethylene glycol) except a. Biocompatible b. Biodegradable c. d. Reduce particle aggregation Increase drug circulation time 2. Small size nanoparticles will be transported by the following mechanism(s) a. Transcellular passive (passive diffusion) b. Transcellular active (carrier-mediated transport) c. Endocytosis d. Paracellular route 3. Typ es of drugs used in polymer-drug conjugates have the following conditions except: a. Hydrophilic b. Hydrophobic c. Low stability Presence of functional groups for conjugation d. 4. Which of the following points is/are false in case of factors affect oral drug delivery! a. intestinal motility b. surface area of the small intestine c. blood supply d. none of the above an are to:

Explanation / Answer

1) Reduce particle aggregation - Polyethylene glycol could theoretically prevent nanoparticle aggregation in pure water. But in physiological conditions of a human body, the high ionic strength compresses the electric double layer on the particle surface. This significantly weakens the repulsion between particles and causes aggregation.

Surfaces covered with PEG are biocompatible. PEG is also biodegradable and they prolong the circulation time of a drug.

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