Sec61 is a protein that is required for transport of newly synthesized ER reside

Question

Sec61 is a protein that is required for transport of newly synthesized ER resident proteins into the ER. Which of the following would you predict to occur if Sec61 were knocked out?

ER proteins would not be able to be translated.

Proteins that should remain in the cytoplasm would end up in the ER.

ER protein levels would build up in the cytoplasm.

ER proteins would be secreted.

ER proteins would not be able to be translated.

Proteins that should remain in the cytoplasm would end up in the ER.

ER protein levels would build up in the cytoplasm.

ER proteins would be secreted.

Explanation / Answer

Which of the following would you predict to occur if Sec61 were knocked out?

C) ER protein levels would build up in the cytoplasm.

D) ER proteins would be secreted.

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