In studying receptor-ligand interactions, the researcher wanted to narrow down t

Question

In studying receptor-ligand interactions, the researcher wanted to narrow down the exact region of binding between the receptor and the ligand. Amino acids 24 – 29 on the receptor were believed to be involved in ligand binding. So the researcher performed mutations in these amino acids and assayed the effect of these mutations by performing binding assays. Mutations Receptor-Ligand binding Amino acid 24 No Amino acid 25 Yes Amino acid 26 No Amino acid 27 Yes Amino acid 28 No Amino acid 29 Yes Amino acids 24+27 Yes.
Question: if the amino acid 24 was mutated from a glycine to an arginine, and the binding assay results were negative, what would you conclude from these results about the role of this amino acid in binding to the ligand? In studying receptor-ligand interactions, the researcher wanted to narrow down the exact region of binding between the receptor and the ligand. Amino acids 24 – 29 on the receptor were believed to be involved in ligand binding. So the researcher performed mutations in these amino acids and assayed the effect of these mutations by performing binding assays. Mutations Receptor-Ligand binding Amino acid 24 No Amino acid 25 Yes Amino acid 26 No Amino acid 27 Yes Amino acid 28 No Amino acid 29 Yes Amino acids 24+27 Yes.
Question: if the amino acid 24 was mutated from a glycine to an arginine, and the binding assay results were negative, what would you conclude from these results about the role of this amino acid in binding to the ligand? In studying receptor-ligand interactions, the researcher wanted to narrow down the exact region of binding between the receptor and the ligand. Amino acids 24 – 29 on the receptor were believed to be involved in ligand binding. So the researcher performed mutations in these amino acids and assayed the effect of these mutations by performing binding assays. Mutations Receptor-Ligand binding Amino acid 24 No Amino acid 25 Yes Amino acid 26 No Amino acid 27 Yes Amino acid 28 No Amino acid 29 Yes Amino acids 24+27 Yes.
Question: if the amino acid 24 was mutated from a glycine to an arginine, and the binding assay results were negative, what would you conclude from these results about the role of this amino acid in binding to the ligand?

Explanation / Answer

What would you conclude from these results about the role of this amino acid in binding to the ligand?

A mutation in amino acid 24 disrupts receptor-ligand binding.

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