Kidney transplat candidate were tested for a potential compatible kidney because

Question

Kidney transplat candidate were tested for a potential compatible kidney because the candidate demonstrated HLA antibodies. The patient's HLA antigens were typed as A1, A2, B27, B50, DR17 and DR11.  Antibodies identified were specific for A3, B18, and DR7 antigens. If the mother's HLA typingis A1, A3, B35, B27, DR4, and DR11, and the father's typing is A2, A24, B50, B44, DR11, and DR17.   List the probable HLA types of the candidate's three siblings. Select the kidney or kidneys with the best match.

Explanation / Answer

The Mother HLA typing A1, A3, B35, B27, DR4, and DR11 cross with father HLA typing A2, A24, B50, B44, DR11, and DR17.

The Results

First sibling - A1, A2, B27, B44, DR4, DR11

Second Sibling - A3, A24, B27, B50, DR11, DDR17

Third Sibling - A1, A24, B35, B44, DR11, DR11

The BEst match First and Third sibling. Both does not contain HLA Antigen A3, B18, and DR7. So it has high chance to accept in the patient.

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