.87 93413.44 18.31 23.21 29.59 15 8.55 14.34 10.31 25.00 30.58 37.30 25 16.47 24
ID: 199893 • Letter: #
Question
.87 93413.44 18.31 23.21 29.59 15 8.55 14.34 10.31 25.00 30.58 37.30 25 16.47 24.34 30.68 37.65 44.31 52.62 67.51 76.15 86.60 50 44. (6 points) Below is a partial pedigree of hemophilia (X-linked recessive) in the British Royal Family descended from Queen Victoria, who is believed to be the original "carrier" in this pedigree. a. (4 points) (no correct answer, 0 point; one correct, 1 point; two correct, 2 points; all three correct, 4 points) By naming three alphabet characters, identify the three people (in addition to Queen Victoria) who are certain to be carriers. (note: Do not put down more than three people, you will get I point deduction/every additional wrong person) b.(2 points) What is the probability that the person a (indicated by a red arrow and ") is a carrier? Albert Victoria (1819-1901) 9 J k Imo P q r s t u w x y z 12Explanation / Answer
Answer:
The X-linked recessive disease occurs in hemizygous males and homozygous females carrying the gene. Therefore mostly are affected than females in this type of inheritance.
a. Individual 'c' can be a carrier, her male partner is unaffected and in their progeny, one of the male is affected by the disease. This has occurred since the affected male progeny has received X chromosome containing the diseased recessive gene from carrier 'c' parent and Y chromosome from an unaffected male parent.
Individual 'f ' can be a carrier since her progeny both male and female are unaffected and may have received the non-diseased allele from mother 'f'
Individual 'i ' can be carrier since her male progeny is affected with X-linked recessive disease and have received the X chromosome carrying the diseased allele from 'i ' mother.
b. Individual 'a' has 50% probability of being a carrier since her male progeny is unaffected and might have received the normal X chromosome from mother 'a'.
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