1-2 affected with recessive X-linked hemophilia A gel patterns show an RFLP of a
ID: 199481 • Letter: 1
Question
1-2 affected with recessive X-linked hemophilia A gel patterns show an RFLP of a DNA fragment is also X-linked and located at a distance shottha 30 percent recombination with the hemo locus. The RFLP alleles are designated as s, which yields the slow-moving band near the top of the ge and f, which yields the fast-moving band near the bottom of the gel. Let A and a represent the nonmu tant and mutant forms of the hemophilia gene, respectively, and assume that the male I-2 is the only possible source of the hemophilia mutation in this pedigree. 5.28 ,In the accompanying pedigree, the male ne e showing ch phili on ns on nes 2 ain the 3 4. eny y do You the 2 epict eces- nked Indi- duals car- now- ated (a) What is the probability that the woman (b) What is the probability that the woman (c) What is the probability that IV-1 is affecte II-3 is heterozygous for the hemophilia mutation is heterozygous for the hemophilia mutation with hemophilia?Explanation / Answer
a 1/2 is the probability that the woman II3 is heterozygous for the haemophilia mutation
b 1/4
c 1/2
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