enzyme to lower the free energy 2. We have covered several factors that allow an
ID: 199054 • Letter: E
Question
enzyme to lower the free energy 2. We have covered several factors that allow an activation of a reaction. Each of the experimental observations below provides support for one of these factors. Identify the factor of A. The acetylcholinesterase-catalyzed hydrolysis of acetylcholine proceeds via two steps: (1) the formation of an acyl-enzyme intermediate between an active-site serine and the acetyl group of acetylcholine; and (2) the hydrolysis of the acyl-enzyme intermediate. B. The binding of Phe-Ply to chymotrypsin leads to the twisting of the planar C. During the reaction catalyzed by lactate dehydrogenase, NADH and pyruvate D. A mutation in chymotrypsin replaces ASP 102 (the one in the active site) with E. The irreversible inhibitor, diisopropyliluorophosphate attaches to SER 195 in peptide bond. are bound adjacent to one another at the active site. isoleucine. This renders the enzyme catalytically inactive. chymotrypsin.Explanation / Answer
Ans-2A the formation of enzyme substrate complex lowers the activation energy for the reaction.
2B- the twisting of the planner bond lead to decrease the strength of the bond. The change in orientation lowers the activation energy.
2C- pyruvic acid is catalysed by lactate dehydrogenase to supply energy to the cells. NADH is reduced to NADPH which lowers the activation energy.
2D- these type of mutation leads to mutated amino acid sequence which is not as strong as real sequence and also the activation energy gets lower for such mutation.
2E- the environment of body parts favors the hydrolysis of amino acids by cymotrypsin. The inhibitor are left inactivated in such condition.
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