i answered this, but needed to check my answer to this. So posting the questions
ID: 198374 • Letter: I
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i answered this, but needed to check my answer to this. So posting the questions on here so I can compare with what I wrote
9. In class, we discussed the following graph. Effect size 50.0 Few examples Rare alleles causing high-eflect common variants influencing disease 3.0 Low-frequency variants with intermediate effect 1.5 Rare variants of small offect very hard to identify Common variants implicated n .by genetic means Low common disease by GWA 0.001 0.05 Very rare Rare 0.005 Allele frequency (a) What is considered to be a common allele? (b) we introduced the APOE 4 allele and its association with Alzheimer's disease. The frequency of APOE 4 allele is 12% to 15% in normal controls and 35% in all patients with AD, which group (indicated with ovals) shall 4 allele fall into? Defend your answer (c) There are few examples of high-effect common variants influencing common disease. List one example. Specify which allele and which disease it is.Explanation / Answer
Answer: Your answer was exactly correct, I will give the justification for that. Generally In Alzheimers Disease, two proteinsi.e., Tau Protein and Beta Amyloid Protein are responsible to cause this disease. In this APOE(Apolipoprotein E) "E4" Allele which is associated with Alzheimers, the frequency of APOE e4 allele is 12% to 15% in normal controls and 35% in all patients with AD(as we can in this Diagram)
If we observe this Allele Frequency, the e4 allele fall in to Low frequency variants with intermediate effect.
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