1. Which of the following does not have C domains in the Ig molecule? a. Whole I

Question

1. Which of the following does not have C domains in the Ig molecule?  a. Whole IgG   b. Fc c. Heavy chain    d. Light chain         e. Fab

2. Which of the following does not bind to Fc receptors? a. Whole IgG          b. Fc c. Heavy chain    d. Light chain

3.  Which of the following is the most abundant isotype in human serum?  a. IgA              b. IgD          c. IgE          d. IgG          e. IgM

4.  All myeloma protein molecules derived from a single clone will have the same idiotype and allotype (True or False)

5. A rabbit immunized with human IgG3 will produce an antibody that reacts with all subclasses of IgG in humans (True or False)

6. All myeloma protein molecules derived from a single clone will have the same idiotype and allotype (True or False)

Explanation / Answer

1. Answer is option a whole IgG. C domains are the regions in immunoglobulins which is invariable in its amino acid sequence. Light,heavy chains, Fab and Fc have c domains.

2. Answer is option b. Fc. Fc receptors usually bind to Fc region and not to Fc. These act as sites for antibody binding and all the others bind to these places.

3. Answer is option d IgG. IgG is the most abundant immunoglobulin and comprises 80% of total serum immunoglobulins.

4. Answer is True. All myeloma protein molecules derived from a single myeloma clone will have same idiotype and allotype.Allotype is the allele of antibody chain and idiotype is the antigen - binding sites which characterize the antibody. If the protein molecules are derived from a single clone everything will be the same.

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