1. Describe in detail how SNARE proteins and other accessory proteins may help i
ID: 197481 • Letter: 1
Question
1. Describe in detail how SNARE proteins and other accessory proteins may help intracellular vesicles to be directed to the correct destination. 2. Discuss a model on how Na - K transporter may function. How is the proper functioning of this pump tied to import of glucose into a cell? 3. Discuss the how oxygen and carbon dioxide is transported in a red blood cell. Discuss what happens regarding the fate of these gases in both the lungs and the tissues. (The ppt slides only describes transport of CO2, you will need to find thoe transport of oxygen part OUTSIDE of the textbook. Feel free to use any A&P; textbook, Wikipedia or any other online resources. You will only get maximum 7/10 for the content score if you only describe CO2 transport)Explanation / Answer
Hi,
SNARE are the small proteins which assist in vesicle transport inside the cell and also during exocytosis. The enzymes and proteins produced in the ER is transported to Golgi bodies. From there the cargo is packed in vesicles and is targeted to destination. These vescicle fusions depend on association with SNARE proteins. They help in binding of the vesicle and to the lipid membrane. These SNARE proteins pull the membrane close and hold them for vesicle exchanges.
The SNARE protein forms alpha-helices to form a coiled coil motif. These complex structures of several SNARE protein bind to the vesicles and start to bind them. This process is energetically expensive. The joining of vesicles is termed as Zippering. The NSF, an ATPase in involved in membrane fusion. The NSF hexamers and alpha-SNAP bind and dissociate the SNARE complex by coupling ATP hydrolysis. this process cycles the SNARE and can be reused.
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