The first two generations of the Smith family, shown below, are healthy, so they

Question

The first two generations of the Smith family, shown below, are healthy, so they are surprised when Laura and her husband Aaron, and Dylan and his wife Iris, have children, that show symptoms of a genetic disorder. Karen, Leslie, and Lance have a rare condition called DiGeorge syndrome. The children have small facial features and low, rotated ears. More serious symptoms are defects in the blood vessels leading from the heart, impaired immunity, and disturbed calcium metabolism. Dylan and Iris consult a genetic counselor, Ms. Reese, who is concerned that their niece Karen has the same syndrome as Leslie and Lance. She learns that Iris has had several spontaneous abortions, as has her sister-in- law, Laura. Noting the combination of repeated birth defects and pregnancy losses, Ms. Reese suggests that Dylan and Laura and their siblings, children, and parents be karyotyped. The results, unfortunately confirm the genetic consoler's suspicions. Perry, Holly, Ariel, Sherri, and Shane have normal chromosomes. Laura, Dylan, Zach and Kim have a balanced reciprocal translocation between chromosomes 20 and 22. They have no symptoms, but are translocation carriers with the following chromosomes ZachAriel Laura |Aaron Perry Brenda Brendalanis Holly Iris Holly Karen Sherri Shane Leslie Lance Kim Translocation Normal 22 Excess 22 Translocation Excess 20 Normal 20 Deficient 22 Deficient 20 Based on the information given above, answer the following five questions: (refer to the reciprocal translocation in the ppts of chapter 6)

Explanation / Answer

5) B because Karen, leslie and lance are the affected members hence they will have partial trisomy 20, and partial monosmy 22.

6) C because Laura and Iris are the reciprocal translocation carrier with partial trisomy in 22 and partial monosomy in 20 which has resulted in their spontaneous abortions.

Related Questions

Navigate

• Browse (All)
• Browse T
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.