Niemann-Pick disease is a rare genetic disease inherited in an autosomal recessi

Question

Niemann-Pick disease is a rare genetic disease inherited in an autosomal recessive fashion. The non-disease allele is D, while the Niemann-Pick disease allele is d. Suppose that that Niemann-Pick disease affects 1:150,000 individuals in a certain population. In all cases (parts a-d), please indicate your answer to four decimal places.

a. What is the frequency of the d allele in this population?

b. What is the frequency of the D allele in this population?

c. What is the frequency of the DD genotype in this population?

d. What is the frequency of the Dd genotype in this population

Explanation / Answer

Answer-

a. In this population, frequency of d allele is 0.0006

i.e 1/150000 * 100 = 0.0006

b. The frequncy of D allele in this population is 1-q= 1- 0.0006

= 0.9994

c.. 0.9988 is the frequncy of DD genotype

as p2 is 0.9988

d. the frequency of the Dd genotype is pq=

0.0005

as p2 + q2 + 2pq= 1

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