Open the webpage https://evobir.shinyapps.io/wf model/ and complete the simulati

Question

Open the webpage https://evobir.shinyapps.io/wf model/ and complete the simulations below. Discuss your results with your lab instructor before you leave the lab SIMULATION 1: Two alleles are present for a particular gene. Run the simulation with all selection coefficients the same (each is 1.0). Leave n-10 and the initial frequency of A at 0.8. Run the simulation 5 times (each time, the simulation will run 100 generations for each of the 10 iterations). Each time you run the simulation, record the number of replicates where f(A) = 1 or f(A) = 0 at Generation 100 # replicates with final f(A) = 1 | # replicates with final f(A) = 0 4 Run 1 Run 2 Run 3 Run 4 Run 5 4 Do you always obtain the same result? Why? I don't obtain the same result because the population is very low even though the frequency of both alleles are the same, both have an equal chance of showing up SIMULATION 2: Increase n to 100 and rerun the simulation 5 times. What do you predict will happen? Why? I predict that overtime one of the alleles will take longer to get lost since it's a much higher population # replicates with final f(A) = 1 | # replicates with final f(A)-0 Run 1 Run 2 Run 3 Run 4 Run 5 What happened? Compare with the results of Simulation 1. The results show that the f(A)-1 got lost much quicker than in simulation 1.

Explanation / Answer

Ans 1) The simulations run for 100 generations in case of each of the 10 iterations. After completion of the simulations, we do not always get the same answer and the results are not always same cross the 5 simulations. It is because of the fact that in this population, genetic drift may occur which might lead to variations in the sample. This variation in the sample leads to all sorts of fluctuations in the allele frequency changing the simulation result.

Ans 2) There is lot of genetic drift based variations observed and it largely depends on the size of the population. So when we increase the n to 100 and re-run the simulation 5 times, there is larger variation observed and seen due to drifting. Hence, we can see that in case of f(A) after re-running the simulation, it got lost much more quickly as compared to the first simulation.

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