K-Ras Berg p. 411-418 downgprolein is directly upstream of Ras and what protein

Question

K-Ras Berg p. 411-418 downgprolein is directly upstream of Ras and what protein is diroctly pathway eam of Has in the epidermal growth factor (EGF) signalling 2. What are the three forms of Ras that mammalian cells contain? Excerpt from Science article: In this article, GDP-CP (guanine 5(D,I-methylene) triphosphate) is a non- hydrolyzable form of GTP (also called a non-active substrate analog). Where are the major structural differences between the GTP-bound and GDP bound forms of Ras? 3. 4. How do the authors explain the interaction between Val at position 12 (Val) and the gamma phosphate of GDP-CP (the GTP analog)? How does your answer to question 5 explain the increase in activated Ras of the Val 12 mutant? 5.

Explanation / Answer

1) The upstream of the Ras is Receptor tyrosine kinase, Shc, GRB2, and SOS

Downstream of the Ras are Raf, Mek, and Erk

2) the forms Ras are H-Ras, K-Ras, and N-Ras

To answer 3,4, and 5 more info needed.

Related Questions

Navigate

• Browse (All)
• Browse K
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.