ble allei ant allele for Huntington disease is seg- The dn in the accompanying p

Question

ble allei ant allele for Huntington disease is seg- The dn in the accompanying pedigree. Affected 615 regating als are shown in green. Also shown is the inoDNA bands observed for a RFLP. The re labeled as 1 and 2. Using HD and hd for uals are pattern s are la band emutant and nonmutant Huntington alleles and A2 for the alleles yielding the RFLP bands and Ai l and 2, respectively a) Deduce the genotype of each person in the pedigree with respect to the Huntington , alleles and to the RFLP alleles (b) Explain why there are no persons who have only the smaller DNA fragment (fragment 2, the lower band). (c) Indicate whether you find any evidence of linkage between the Huntington gene and the RFLP (d) If you do see evidence of linkage, list each person who carries a recombinant chromosome according to the numbers across the bottom of the gel. e) Estimate the frequency of recombination between the Huntington gene and the RFLP

Explanation / Answer

b) A2 allele is rare,so by chance A2A2 homozygous person do not occur in sample aso A2 allele could be associated to HD.
c)the evidence of linkage is there as most person who inherit HD also inherit A2 allele associated to dominant allele in this given pedigree.
d) the recombinant sample appear in chromosome number: 1, 10, 12,24,25
e)in 25 persons recombinant chromosome could be detected, among these 5 carry recombinant chromosome, estimated frequency of recombination = 5/25= 20%

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