Question 4 (5 points) Imagine you are Randy Sheckman and you are trying to provi

Question

Question 4 (5 points) Imagine you are Randy Sheckman and you are trying to provide additional evidence for your model of how vesicles move from the ER to Golgi (shown below). A graduate student in your lab has created a yeast strain that has a mutant form of Sarlp. She purified this mutant protein and showed that it could bind GTP, but could not hydrolyze it. You suggest that she compare the protein from her mutant to the protein from wild-type cells in a vesicle budding and fusion experiment (like the one we examined in class) Sar1p Sec 10p complex Sec23p complex GTP GMP -PNP Sec12p Endoplasmic Reticulum Golgi Complex Vesicles

Explanation / Answer

I believe the correct answer to be option B) vesicle budding and fusion will occur with the wild type protein, but only buddinf will occur at a significant level with a mutant protein.

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