1. In the hippocampus, neurons in the dentate gyrus sends their excitatory outpu
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Question
1. In the hippocampus, neurons in the dentate gyrus sends their excitatory output mainly to: 2. Compared to passive membranes in the dendrites, the amplitude of back-propagating action potentials is larger or smaller when the dendrites contain voltage-gated Na channels? 3. Why does the width of the action potential affect synaptic release? 4. For grasshopper mice, why does the presence of the scorpion venum reduce action potential firing? 5. For feedback inhibition, high levels of activity in a pyramidal neuron would lead to: 6. SOM+ GABAergic interneurons synapse on distal dendrites. PV+ GABAergic interneurons synapse on the soma. What could you do to SOM+ interneurons to make their inhibitory effect on the pyramidal neuron comparable to that for PV+ interneurons?Explanation / Answer
1). The dentate gyrus is made-up of the polymorphic layer which is the mainly outward cover of dentate gyrus and it is considered a separate subfield. This Polymorphic layer contains a lot of interneurons, and axons of the dentate granule cells. The part of the hippocampus which contains the cell bodies of the dentate granule cells is called as Stratum granulosum. The Stratum molecular is divided into two parts the first part, where both commissural fibers from the contralateral dentate gyrus run and form synapse as well as where inputs from the medial septum terminate is known as Stratum molecular (1/3 part). Stratum molecular (2/3 part) is the deepest part, meeting presently exterior to the hippocampal sulcus and making excitatory synapses on the top of the distal apical dendrites of granule cells.
So the hippocampus neurons in the dentate gyrus send their excitatory output mainly to synapses on the top of the distal apical dendrites of granule cells.
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