1. From primary sequence to secondary structure (18 points). Answer the followin
ID: 192377 • Letter: 1
Question
1. From primary sequence to secondary structure (18 points). Answer the following questions based on these three primary sequences: I. FQIDMELKV Il. AQYGPNLPA IIl. FNSVLQDIE a) which sequence is most likely to form a -strand, with one surface facing the protein interior and the other exposed to water? Justify your answer with one sentence. b) Which sequence is most likely to form an amphiphilic a-helix? Justify your answer with one sentence and a helical wheel diagram. c) which sequence is unlikely to form either -sheet or a-helical structure? Justify your answer with one sentence.Explanation / Answer
A) The sequence which is most likely to form a B-strand is the second one as it is having a glucine in the middle which has the maximum flexibility in all the aminoacids and hence a peptide can be bent on that location.
B) according to me, the amphiphellic helix would again be the second sequence as it has the AQY part hydrophillic while the rest is mostly hydrophobic.
C) IKLM are all large amino acids and hence they prevent the formation of secondary structures and they are all present in sequence 1.
THESE ANSWERS ARE TO THE BEST OF MY KNOWLEDGE AND RESEARCH.
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