16. You are provided below with the nature of the side chain of 5 amino acids. P

Q: 16. You are provided below with the nature of the side chain of 5 amino acids. P

a Non-polar B, E b Polar uncharged C, c Polar C, d beta-sheets E,C e Aqueous pore D, A f Transmembrane E, g Aqueous pore+ Transmembrane B, C a Non-polar B, E b Polar uncharged C, c Polar C, d beta-sheets E,C e Aqueous pore D, A f Transmembrane E, g Aqueous pore+ Transmembrane B, C

ID: 191793 • Letter: 1

Question

16. You are provided below with the nature of the side chain of 5 amino acids. Please use the provided letters (A, B, C, D, and E) to answer the questions (a) to (g). No partial credit will given for given (a) to (g) Cthreonine D glutamicE phenylalanine Lys, or K) (Ala, or A) (Thr, or T) (Glu, or E) (Phe, or F) H O H O H O H O H O H CH H CH--CH H CH OH NH (a) Which amino acid(s) are non-polar (1 point) (b) Which amino acid(s) are polar uncharged (1 point) (c) Which amino acid(s) are polar charged (1 point) (d) Which amino acid(s) would you expect to find in a -sheet (2 points) The figure below displays a channel, and is categorized as a transmembrane proteirn queous pore helix lipid bilayer (e) Which amino acid(s) would you expect to find preferentially in the aqueous pore (1 point) (f) Which amino acid(s) would you expect to find preferentially in the outside of the transmembrane -helixes (ie, in contact with the lipid bilayer) (1 point) (g) Which amino acid(s) would you expect to find equally represented in both aqueous pore and outside of the transmembrane -helixes (1 point) (h) Draw the condensation reaction of a glutamic acid and an alanine (use the side chain provided above). Indicate the appropriate charges at pH 7.0. (6 points)

Explanation / Answer

Non-polar

B, E

Polar uncharged

Polar

beta-sheets

E,C

Aqueous pore

D, A

Transmembrane

Aqueous pore+ Transmembrane

B, C