|You are testing a new inhibitor of Na+/H+ exchangers using sea urchin eggs. wha
ID: 191546 • Letter: #
Question
|You are testing a new inhibitor of Na+/H+ exchangers using sea urchin eggs. what effects would this drug be expected to have on a fertilized sea urchin egg? Explain your reasoning 1. You treat amphibian oocytes with xestospongin C, a drug that interferes with inositol triphosphate (IP3) signaling. What effects would pretreatment with the drug have on the eggs after fertilization? 2. 3. Egg and sperm movement both require cilia-like structures. What do these structures do in each case, and what are these structures called? Imagine you are a doctor explaining the process of preimplantation genetic diagnosis to a couple seeking in vitro fertilization. Explain to this couple why preimplantation genetic diagnoses need to happen at a specific stage of development. 4. Determine whether or not fertilization would be successful if the given sperm is allowed to interact with the given egg in the lab 5. Type of egg Is fertilization successful? Type of sperm Sea urchin sperm not exposed Normal sea urchin egg from the to egg jelly same species with its egg jelly removed Normal sea urchin egg from a different species Sea urchin sperm exposed to Mouse sperm extracted directly Mouse oocyte with normal cumulus from seminiferous tubules Normal sea urchin sperm complex Sea urchin egg held at a constant +20mV by using an electrophysiological voltage clamExplanation / Answer
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The drug was originally designed as an Na+ channel blocker in epithelial cells on Na —H+ exchange was surprising. The activation of Na+–H* Exchange The initial work on sea urchin eggs and fibroblasts was consistent with the idea that receptor-induced increases in cytosolic Ca2+
The Na. +./H. -. Exchanger. NHE is an integral membrane glycoprotein expressed ubiquitously in mammalian cells, and it electroneutrally ex- changes . thet fertilization of sea urchin eggs was followed by a rise in. effects of the Na(+)/H(+) exchange inhibitor .
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