10. People with lactose intolerance are able to take products such as Lactaid th

Question

10. People with lactose intolerance are able to take products such as Lactaid that contain the lactase enzyme with their meals. These products can be taken in pill form. Considering the fact that the pill form of the enzyme would have to travel through the person's stomach to arrive in the intestines where it will do its job, what special consideration would the producer of this product need to be concerned about to ensure the product will be effective? 11. Mr. Smith loves ice cream but he stopped eating it years ago due to lactose intolerance. When his friend Bob told him about lactaid he was so excited to try it that he went out right away and purchased a box of lactaid and a gallon of ice cream. The next day Mr. Smith called Bob and told him that lactaid doesn't work because he took one pill before he ate the gallon of ice cream and he still ended up with all the symptoms of lactose intolerance. Considering what you've learned about enzyme function in this lab, what should Mr. Smith have done to prevent the symptoms of lactose intolerance? Dann/au ch Au Rights Resened Page 3 of3

Explanation / Answer

The liver is the primary organ of drug metabolism. The gastrointestinal tract is the most important extrahepatic site. The biological barriers such as proteolysis in stomach, variable pH, poor permeation and membrane efflux that restrict absorption from the gastrointestinal (GI) tract have to be overcome by the drug. Protein absorption through the stomach is limited by several factors such as low surface area, action of pepsin and harsh degradative acidic environment. Thus the producer of the lactaid tablet should ensure a gastroresistant film over the pills for stomach residence and facilitate time-dependent colon delivery. Also since the stomach's environment is acidic in nature, the drug can be made alkaline so that it escapes the stomach region and succesfully reaches its target.

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