These are the only two pages on the homework assignment Cystic fibrosis is a gen

Question

These are the only two pages on the homework assignment

Cystic fibrosis is a genetic disease caused by a loss-of-function mutation in a chlorine channel, and causes a thickening of the mucus leading to respiratory failure. The disease is autosomal recessive, and affects 1 in 2,500 newborns. Fill in the following values (1 point each): P0.98 0.02 Assume you have a population of 100,000 people How many carriers are in the population? (1 point) Show your work E 3920D How many healthy individuals are in population? (1 point) Show your work Reminder: only homozygous recessive individuals are sick 3920t(0985% 100,000

Explanation / Answer

Number of degrees of freedom = 2

The chi square value for this Df is 5.991

The theorotical value is much smaller than the calculated value. We reject the null hypothesis that population is in H-W equilibrium.

CC Cc cc Total Expected number of individuals 98000 3920 2000 100,000 Observed number of individuals 99700 598.2 300 100,000 (O-E)2/E 29.49 2814 1445 4288.49

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