Question 4 O pts Pertussis toxin (PT) is a protein-based toxin produced by the b

Question

Question 4 O pts Pertussis toxin (PT) is a protein-based toxin produced by the bacterium Bordetella pertussis, which is the causative agent of whooping cough. Interestingly, this toxin is solely responsible for all of the symptoms associated with pertussis. Given the image below, answer the following: Side view Top view 1. How many subunits are in this protein? 2. How many polypeptides are in this protein? 3. How many unique polypeptide sequences are in this protein? 5. Based on your answers in i-iv, what terminology would you use to describe this protein to a colleague? Hint: Consider our description of hemoglobin as it pertains to the nature and number of subunits contained therein. 6. Identify two different forms of secondary structure in this protein (use arrows and label them appropriately). If one type of secondary structure is not present, indicate so in your answer below.

Explanation / Answer

Pertussis toxin:
It is an exotoxin produced by the bacterium Bordetella pertussis.
It is the causative agent of whooping cough.
Target area = Respiratory tract.

Number of subunits = 6
Number of polypeptides = 6
Number of different polypeptides = 2
Structure shown = Quaternary structure
Terminology = AB5
Secondary structures present = Alpha helices (surrounding ribbon like helices) and beta sheets (Bottom barrel).

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