The family tree in Fig. 1 illustrates the inheritance of a rare disease conditio

Question

The family tree in Fig. 1 illustrates the inheritance of a rare disease condition that manifests itself after age 40. Individuals marked by the ? are too young to be diagnosed. Assume (regardless of what data are suggesting) that the P locus is at 5 m.u. from the locus causing the disease. What is the probability that Maria is affected and carries allele P4?

0/ 2 pts Question 8 Frank P5 P7 P4 P2P7 P9 P3P1Joe P2 P7 P2 P7 P4 P7 P2 P9 P4 P9 P4 P P locus' different alleles shown by number Maria Figure 1 The family tree in Fig. 1 illustrates the inheritance of a rare disease condition that manifests itself after age 40. Individuals marked by the? are too young to be diagnosed. Assume (regardless of what data are suggesting) that the P locus is at 5 m.u. from the locus causing the disease. What is the probability that Maria is affected and carries allele P4? You Answered 0.12 Correct Answer 0.22 0.47 0.5 0.025

Explanation / Answer

Answer : Choice 2

Explanation: According to the information, the P and disease locus are located only 5mu apart. This strongly suggests that these two loci will be linked to each other. Considering the pedigree, it can be seen that there would br 50% probability that the P and disease loci would be transferred to next generation from Frank, i.e. 0.5. Nect, the chances of transferring these loci frkm F1 to Maria would be again halved i.e.50/2 or 25% or 0.25. Thus, the closest answer is given by choice 2.

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