(3) There appear to be two populations of monocytes (CD2+ Mo and CD2-Mo). CD2 is

Question

(3) There appear to be two populations of monocytes (CD2+ Mo and CD2-Mo). CD2 is an immune cell marker that may indicate differentiation into dendritic cells (DC). Briefly explain how this suggests (supports) the hypothesis that monocytes circulating in the blood can differentiate into DC (to "MDC1" populations of DC bylines in the Myeloid immunophenotyping diagram, above), rather than only bone marrow progenitors differentiating into DC. What other marker(s) might you look for on CD2+ Mo in the PBMC that would further distinguish them as DC precursors?

Explanation / Answer

Monocytes are circulating mononuclear phagocytes which can differentiate into macrophages and when exposed to the right environmental conditions can be also re-directed to dendritic cells. Circulating CD2+ and CD2- monocytes are dendritic cells and the precursors of macrophages, respectively. The markers that could be used are CD2, CD14, and TCR Ags.

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