Which aspect of DNA is distinct between the two forms of DNA and may affect the

Question

Which aspect of DNA is distinct between the two forms of DNA and may affect the stability of the structure?

A. bases do not stack in Z-form DNA

B. Z-form DNA is left handed

C. Z-form DNA has phosphates on the inside of the helix

D. Z-form DNA does not have a major/minor groove

Which molecule would be most likely to disrupt base stacking interactions?

A) Glucose

B) Cyclohexane

C) Phosphate

D) A planar aromatic molecule

If two bases in a DNA molecule were moved away from the parallel orientation in DNA such that one base was 45 degrees relative to the other base, would the interaction energy increase, decrease or stay the same?

A) increase

B) stay the same

C) decrease

Explanation / Answer

Answer 1. A. Bases do not stack in Z form DNA.

In Z DNA bases do not stack on each other equivalently. Stability of the DNA double strand depends upon various weak interactions such as hydrogen bonds, base stacking and hydrophobic effects. Amongst these, stacking interactions are the most important.

Answer 2. Cyclohexane

Answer 3. Decrease

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