7. Amino Acid Sequence and Protein Structure Our growing understanding of how pr

Question

7. Amino Acid Sequence and Protein Structure Our growing understanding of how proteins fold allows research- ers to make predictions about protein structure based on pri- mary amino acid sequence data. Consider the following amino acid sequence. 2 4 5 7 8 9 10 Ile-Ala -His -Thr-Tyr -Gly -Pro -Phe -Glu -Ala 11 12 13 14 15 16 17 1819 20 Ala -Met-Cys-Lys -Trp-Glu -Ala -Gln -Pro -Asp 21222324 25 262728 Gly-Met-Glu -Cys-Ala -Phe -His-Arg (a) Where might bends or turns occur? (b) Where might intrachain disulfide cross-linkages be formed? (c) Assuming that this sequence is part of a larger globular protein, indicate the probable location (external surface or of the following amino acid residues: her ntEEK d, Brgbay

Explanation / Answer

Answer:

(a)glycine- Proline (position 6 and 7) most likely to form beta turns

(b)disulfide bridge can form between the sulfhydryl groups of Cystiene13- cysteine 24

(c)According to hydropathic index

Hydrophilic: lysine, Asp, glutamine, threonine

Hydrophobic: Ile, Ala

The hydrophilic amino acid residues are most likely to be found on the exterior of the globular protein, while the hydrophobic amino acids in the interior of the globular protein.

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