7. Which of the following drugs would be expected to reduce movement of mitochon

Question

7. Which of the following drugs would be expected to reduce movement of mitochondria in nerves? Mark all that apply Excess 3-0-methyl glucose in the medium (prevents glycolysis by reducing glucose uptake by cells) FCCP (inhibits mitochondrial production of ATP) Cytochalasin D (disrupts actin filaments) BDM (inhibits myosin motor activity) o 8. Actin monomers (globular actin or G-actin) are organized into linear, double-stranded microfilaments which undergo constant formation by polymerization and destruction by depolymerization, so changes in the structure of actin filaments can occur quickly by balancing or unbalancing these processes. Cytochalasin D is a drug isolated from mushrooms that inhibits actin polymerization, while leaving depolymerization unaffected. The figure shows rates of cytoplasmic streaming in Nitella under control, after addition of Cytochalasin D and then following washout of the drug. Mark on the figure one time each when () polymerization> depolymerization and (ii) depolymerization> polymerization of actin filaments. 60 50 40 30 20 10 0 5 10 1 20 25 30 35 Time (min) 10

Explanation / Answer

Mitochondrial motility is very Essential in nerve cells, because mitochondria involves in ATP production as well as ca++ reservoir in cells and the distribution of mitochondria change from cell body to pre synaptic and post synaptic ends of nerve cells for the maintenance the homeostasis of CA++ and ATP. Mitochondria move in cells with the help of micro tubules and for this motility cells depend on energy, which is generated by metabolic pathways in cells. Excess 3-0 methyl glucose prevent the uptake in cells. The glucose is essential for operating central metabolic pathway in cell for energy generation.due to prevention of uptake of glucose cells can not synthesise the needed amount of energy for polymerisation and depolarisation of micro tubules and due to this mitochondrial motility disturbs. This disturbance of mitochondrial motility leads to neurological dysfunctioning.

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