21. Sequence Comparisons Proteins called molecular chaperones (described in Chap

Question

21. Sequence Comparisons Proteins called molecular chaperones (described in Chapter 4) assist in the process of protein folding. One class of chaperones found in organisms from bacteria to mammals is heat shock protein 90 (Hsp90) All Hsp90 chaperones contain a 10 amino acid "signature sequence" that allows ready identification of these proteins in sequence databases. Iwo representations of this signature sequence are shown below. Y-x-[NQHD]-[KHR]-[DE]-[IVA]-F-CLM]-R-[ED] YSNKEIFLRE 4 2 0 1 23 4 5 6 789 10

Explanation / Answer

a.)Position 1 (Y), Position 7(F) and Position 9(R) are the amino acids found conserved across all species. This can be concluded from comparison of multiple species.

b.)Position 4 (K) Lys is more common & Position 9(R) Arg is invariant. These both the amino acids are positively charged as per there general properties.

c.)Position 5 and 10 (E) Glu are common at both positions.

d.)Position 2(S) Ser appearing most often.

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