1. When glucose is oxidized via glycolysis, the carbon atom that bears the phosp
ID: 188016 • Letter: 1
Question
1. When glucose is oxidized via glycolysis, the carbon atom that bears the phosphate in the 3- phosphoglycerate formed may have originally been either C-1 or C-6 of the original glucose. Describe this pathway in just enough detail to explain this.?
2. Explain in quantitative terms the circumstances under which the following reaction can proceed.
Citrate isocitrate G'° = +13.3 kJ/mol
3. Does a low activation energy for a forward reaction contribute to a large, negative, free-energy change upon hydrolysis of “high-energy” compounds? Explain.
4. In glycolysis there are two reactions that require one ATP each and two reactions that produce one ATP each. This being the case, how can fermentation of glucose to lactate lead to the net production of two ATP molecules per glucose?
5. All of the intermediates in the glycolytic pathway are phosphorylated. Give two plausible reasons why this might be advantageous to the cell.
Explanation / Answer
Answer:
1. When glucose is oxidized via glycolysis, the carbon atom that bears the phosphate in the 3-phosphoglycerate formed may have originally been either C-1 or C-6 of the original glucose. Describe this pathway in just enough detail to explain this.?
2. Explain in quantitative terms the circumstances under which the following reaction can proceed.
Citrate isocitrate G'° = +13.3 kJ/mol
3. Does a low activation energy for a forward reaction contribute to a large, negative, free-energy change upon hydrolysis of “high-energy” compounds? Explain.
4. In glycolysis there are two reactions that require one ATP each and two reactions that produce one ATP each. This being the case, how can fermentation of glucose to lactate lead to the net production of two ATP molecules per glucose?
5. All of the intermediates in the glycolytic pathway are phosphorylated. Give two plausible reasons why this might be advantageous to the cell.
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