3. Which of the following is a modification of antisense oligonucleotide structu

Question

3. Which of the following is a modification of antisense oligonucleotide structure to increase intracellular stability? a. insertion of an amine into the ribose ring to create a morpholino structure b. attachment of nucleic acid bases to a peptide backbone instead of a c. replacement of one of the oxygen atoms in the phosphate group with a d. addition of an O-alkyl group to the 2-OH of the ribose group to make the e. all of the above sugar-phosphate backbone sulfur atom to inhibit nuclease degradation in some molecules molecule resistant to nuclease degradation

Explanation / Answer

Question 3

Answer is c

Replacement of one of the oxygen atoms in the phosphates group with a sulfur atom to inhibit nuclease degradation in some molecules

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