Suppose a geneticist mutates the gene for the poly(A) tail-binding protein (PABP

Question

Suppose a geneticist mutates the gene for the poly(A) tail-binding protein (PABP) in an eukaryotic cell line. The resulting mutant protein cannot bind to poly(A) tails. What is the effect of the PABP mutation in the cultured cells?

I keep going back and forth between the answer marked and the one immediately below it. Can you please clarify which one is correct and why?

o 1/30/2018 09:30 AM 0 72.9/100 1/28/2018 08:35 PM Gradebook Print Calculator Periodic Table Question 23 of 28 Map cs: A Conceptual Approach 6th MHE/Freeman by Sapling Learning Pierce Suppose a geneticist mutates the gene for the poly(A)tail-binding protein (PABP) in an eukaryotic cell line. The resulting mutant protein cannot bind to poly(A) tails What is the effect of the PABP mutation in the cultured cells? Replication will not occur in the cultured cells, because PABP determines the location of the origin of replication Transcription will not occur in the cultured cells, because PABP is an essential transcription factor Transcription will occur in the cultured cells, but the resulting transcript will be longer than normal Translation will occur in the cultured cells, but the resulting polypeptide will be longer than normal Translation will not occur in the cultured cells, because mRNAs will be degraded at a greater rate than normal Previous Check Answer Next Exit Hint

Explanation / Answer

What is the effect of the PABP mutation in the cultured cells?

E) Translation will not occur in the cultured cells, because mRNAs will be degraded at a greater rate than normal.

The poly(A) tail-binding protein (PABP) protects the tail of mRNA from degradation and regulates mRNA production. Without this protein, the poly(A) tail would not be added and the RNA would degrade quickly.

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