Suppose a novel disease has been studied in several families and is known to be

Question

Suppose a novel disease has been studied in several families and is known to be caused by a mutation in one gene. The table below shows families where the disease is present. The four rightmost columns are the offspring of the father and mother listed in that row. Select the most likely mode of inheritance of the disease Normal Disease autosomal dominant Family Father Mother Male Female Male Female Disease Normal 2 Disease Normal 0 ase2 2 ase0 O X-linked dominant 2 autosomal recessive 0 X-linked recessive Normal Dise Disease Normal Normal Dise 0 2 0 ormal | Disease 2 0 Select the description that best matches the male parent in family 6 Select the description that best matches the female parent in family 3 O O has no disease alleles has one disease allele has two disease alleles O O O has one disease allele has two disease alleles has no disease alleles

Explanation / Answer

The given disorder follows X-linked dominant inheritance pattern.
Reason: When the father is affected, no male kids are affected (be it male or female).

Family 6:
Male parent = WT for X-linked allele
Female parent = Heterozygous for the disease-causing allele

Family 3:
Male parent = WT for X-linked allele
Female parent = Heterozygous for the disease-causing allele

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