In newly formed neural tube, the intermediate region close to the sulcus limitan

Question

In newly formed neural tube, the intermediate region close to the sulcus limitans has been not exposed to molecules that induce ventral or dorsal characteristics. You perform explant experiments in which you take intermediate neural tube (host tissue) and culture them with donor tissue explants that induce specific spinal cord markers in the host explant. We would appreciate succinct answers (not to exceed the space or past the lines), and typing is also appreciated! 1. The induced host tissue expresses Shh following transplant. A. (4 points) What donor tissue have you explanted next to the host tissue, what signal is released to induce this marker, and what cell type has been induced? Briefly explain your reasoning B. (2 points) What other cell types do you expect to observe? Briefly explain your reasoning. (4 points). The induced host neural tube expresses HB9. What donor tissue have you explanted next to the host tissue, what signal is released to induce this marker, and what cell type has been induced? Briefly explain your reasoning. 2.

Explanation / Answer

1a.we explant notochord near the host tissue The donor tissue releases a morphogen called sonic hedgehog which induces neuroepithelial cells to differentiate into prospective neural structures.

b. Shh also induces differentiation of angiogenic and osteocytes.

2.HB9 is expressed by motor neurons of developing CNS. This expression is induced by signals released from notochord like shh And Ra

3.These signals work via different concentration gradients along the anterio posterior neural axis. This is called as process of patterning.

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