12. What is positive cooperativity? 13. Which of the following is true about pro
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Question
12. What is positive cooperativity? 13. Which of the following is true about protein folding? A) Amino acids cluster in the primary sequence so that all the hydrophobic amino acids are near each other to facilitate folding into the hydrophobic core of the tertiary structure. B) All known proteins have well-ordered conformations C) Amino acids with hydrophobic, nonpolar side chains stabilize the tertiary structure through hydrogen bonding with water molecules surrounding the proteins. D) Elements from the secondary structure are maintained in the tertiary structure 14. What role does aberrant protein folding play in the development of a disease such as Alzheimer's disease?Explanation / Answer
Answer-
12.
Positive cooperativity is one manifestation of the enzymes or receptors that have multiple binding sites where the affinity of the binding sites for a ligand is apparently increased. For example each hemoglobin molecule can bind up to four oxygen molecules. Hemoglobin exhibits cooperative binding, as oxygen binding increases the affinity of hemoglobin for more oxygen..
13.
B) All known proteins have well orded conformation
14,
In Alzheimer's disease, the mis-folded protein deposited in brain is called as A beta oligomers or Tau protein. They block the proper neurotransmission from one neuron to other. Hence disturbs the good healthy memory formation. In the memory area i.e in hippocamppus , these mis-folded Tau proteins deposited more amount..
Hence result memory impairment or memory loss called dementia.
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