A couple wants to know the probability that their ex pected child will suffer fr

Question

A couple wants to know the probability that their ex pected child will suffer from split-hand deformity which affects the prospective father, who is indicated by an arrow in the pedigree shown. (The arrow mean that he is the proband-the person in the family who first brought the disorder to the attention of medical professionals.) This trait, shown in the following photo, is rare in the population, and the prospective parents are not related to each other Source a. What is the mode of inheritance of this trait? b. What is the penetrance of this trait [that is, the ratio between the number of individuals in the pedigree who display the trait (numerator), and the number of individuals you know from the pedigree must have the trait-determining genotype regardless of whether they have the trait or not denominatool? c. Using your answer to part (b) above, what would you tell the parents about the numerical likeli- hood their expected child will have split-hand deformity? d. Why is it possible that the likelihood the child will be affected is actually less than the number you just answered in part (c)? You should specify lowest numerical likelihood that could possibl consistent with the data.

Explanation / Answer

We can not predict any possibilities for affected individual in case of slit hand deformity because in some case the inheritance pattern is autosomal dominant and in some cases it is X linked recessive. slit hand deformity are due to random (sporadic) mutations.

As shown by arrow. the effected inviduals have absolutely normal parent. but still from their previous case we can say that the baby girl may have heigher chance of being affected. in this case prenatal diagnosis for slit hand deformity is required.

Related Questions

Navigate

• Browse (All)
• Browse A
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.