2. Some cases of non-insulin dependent diabetes result from the genetic changes

Question

2. Some cases of non-insulin dependent diabetes result from the genetic changes that lead to the synthesis of dysfunctional insulin receptors? 3. Explain why oral insulin is not a viable option at the current time Some types of diabetes result from alterations of the insulin receptor (fewer than normal or less functional than normal receptors) while some types of diabetes result from the destruction of B cells of the islets of Langerhans of the pancreas, resulting in he inability to make insulin. Non-insulin dependent diabetes represents about 80% of he cases, while insulin dependent diabetes represents about 20% of the cases. a. Describe, to your best recollection, a receptor.

Explanation / Answer

1.Receptors can be described protein molecules that may be present outside the cell i.e the cell membrane or inside the cell i.e cytoplasm and nucleus that binds to specific signal molceules such as hormones, neurotransmitters,antigen etc and responds to it by initiating a signalling process in the cell that in turn arouses a cellular response.

2.Yes, some cases of non-insulin dependent diabetes result from the genetic changes that lead to the synthesis of dysfunctional insulin receptors.Genetic changes due to mutation can lead to dysfunctional insulin receptors.It has ben reported that any mutation in that results in a change in position of methionine at position 1153 to isoleucine results in tyrosine kinase-deficient insulin receptor mutation which is dysfunctional.Also,another insulin receptor dysfunction results due to mutation on the ATP-binding site that replaces lysine present on position 1030 with alanine.When such mutations occur dysfunctional insulin receptors are formed that are impaired resulting in obesity, diabetes, and insulin resistance syndrome.

3.Oral insulin is not a viable option at the current time because:

Related Questions

Navigate

• Browse (All)
• Browse 2
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.