-233-0-11286-Human Anatomy & Physiology III me Content Discussions Assignments Q

Question

-233-0-11286-Human Anatomy & Physiology III me Content Discussions Assignments Quizzes Grades Classlist Help nts > Materials for 1st exam > 233 Study Guide for exam #1 Study Guide for exam #1 82. How does hemoglobin's oxygen affinity change in response to increased bodytemperature the molecular level, what two things are happening to hemoglobin to cause this change in affinity? 83. Which chemical do the chemoreceptors of the body respond most strongly to, in order to initiate the adjustment of respiratory rate? What chemical has the second greatest stimulatory effect on the body's chemoreceptors? Third-most? Which chemoreceptors (central or peripheral) play the largest role in sensing changes to CSF and blood levels of respiratory gases and acids?

Explanation / Answer

82) Reaction when the temperature is increased and the condition of Hemoglobin-O2 affinity:

A negative allosteric effect is seen with increased body temperature. This reduces hemoglobin O2affinity in a febrile patient, allowing increased unloading of O2 during accelerated metabolism in tissues.The Bohr effect refers to the loss of affinity for O2 with decreasing pH (increased acidity), as occurs in the microcirculation as oxygen is consumed and CO2(carbonic acid) is released by tissues. This can be better undertsood by the oxygen–hemoglobin dissociation curve, also called the oxyhemoglobin dissociation curve or oxygen dissociation curve (ODC), is a curve that plots the proportion of hemoglobin in its saturated (oxygen-laden) form on the vertical axis against the prevailing oxygen tension on the horizontal axis.

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