Question 4 Not yet answered Points out of 1.00 P Flag question The sequence of a
ID: 185531 • Letter: Q
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Question 4 Not yet answered Points out of 1.00 P Flag question The sequence of amino acids of the protein insulin is known. Following is a list of amino acids and the number of each in insulin. Insulin Amino acid alanine arginine asparagine aspartic acid cysteine glutamic acid glutamine glycine histidine isoleucine Amino acid leucine 6 5 lysine 20 13 methionine phenylalanine proline serine threonine 12 13 14 tryptophan tyrosine valine 4 A) Based on this table and the structures of the amino acids (Figure 5.14 in your textbook), how many negatively charged amino acids are present in this molecule? B) Based on this table and the structures of the amino acids, how many positively charged amino acids are present in this molecule? B) Based on this table and the structures of the amino acids, how many polar (but not charged) amino acids are present in this molecule? C) What is the maximum number disulfide bonds this protein can have? D) This protein has 179 amino acids. Based on the amino acid composition, this protein is O predominantly neutral O negatively charged Opositively chargedExplanation / Answer
6.
A.Ans-2
Aspartic acid and glutamic acid
B.Ans- 3
Arginine, histidine, and lysine
C.Ans-9
Glycine, alanine, valine, leucine, isoleucine, methionine, phenylalanine, tryptophan and proline.
D.Ans-3
Insulin molecule has two peptides chains such as A chain and B chain. There is two disulfide bond between A and B chains and one additional disulfide bond is formed in A chain.
E.Ans- negatively charged.
The protein molecules are negatively charged when pH > pI. The pI of this molecule is 5.4 at pH between 8.2 and 7.4. The carboxylate group cleaves the hydrogen bond between insulin and phosphate groups of the layers and formed negatively charged insulin molecule.
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