please show work.... PS2-W18 NAME(S) Remember that most of the points come from
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PS2-W18 NAME(S) Remember that most of the points come from how well you show your work (explain your logic). What should be included and their worth Element Appropriate Symbols used and defined Value Your score Pedigree is included with relevant people indicated named Calculations of chance/inheritance shown on the pedigree* Chances shown in an overall calculation 2 Chances in overall calculation clearly labeled Chances appropriately combined with product and/or sum rule2 TOTAL *pedigree can be replaced with equivalent text 10 In the world visited in The Flintstones, there is an autosomal recessive disorder called reduced speech. This condition (probably inherited from Neaderthals) changes the shape and position of the larynx so that many fewer sounds can be made; it is very rare. Fred's maternal uncle had this disorder, as did Barney's paternal grandfather. If Fred's daughter Pebbles and Barney's son Bamm-Bamm were to have a child together, what is the chance that their child would be affected?Explanation / Answer
According to the information, the disease is inherited in autosomal recessive manner in the family. Let us assume that the gene responsible for this disease of reduced speech is given by r and the dominant gene is given by R. Thus, an affected person would have genotype rr.
According to the information, the maternal uncle of Fred was affected and hence, it is very likely that Fred's mother was a carrier of the disease. This also provided a chance that Fred too is a carrier of the disease and would have genotype Rr.
Similarly, it is also suggested from the information that Barney's paternal grandfather was affected and hence, there are 50% chances that Barney herself is a carrier, i.e. genotype Rr.
Thus, the Punnett square between the cross can be made as below:
Genotypes: RR : Rr: rr
Phenotpye: Normal: Normal carrier: affected : 1:2:1 or Normal : carrier : 3:1
Thus, this suggests that there are 25% chances that either of the kids is affected from the disease irrespective of their sexes. This is because the disease is autosomal in nature, not sex-linked.
The probability that these kids, i.e. Pebbels and Bamn-Bamn would have affected kids can be formulated as below:
Thus, genotype: RR: Rr: rr :: 1:2:1
Phenotype: Normal : affected : 3:1
Thus, 25% of their kids are expected to be affected with this rare disease.
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