5. You want to set-up a new Biotech company which will produce recombinant vacci

Question

5. You want to set-up a new Biotech company which will produce recombinant vaccines against influenza stains which infect people especially in Turkey. To produce vaccine for 2013, you want to produce rec minidase from several influenza strains which have infected Turks in 2012. As shown in the phylogenetic tree figure for neuraminidase based on genetic evidence (below), there are about 12 such strains which have infected Turks in the last 12 years, but you can only produce 3 proteins because of the limited resources of your company. Which 3 neuraminidase genes would you like to pick to make proteins from, to put into your vaccine? Please explain your logic briefly 10 9 12 2000 2002 2004 2006 2008 2010 2012

Explanation / Answer

The gene for hemagglutinin (HA )protein, induces an immune response and people become immunized for that flu. The gene for live attenuated influenza vaccine (LAIV) enhanced cell-mediated responses. We also use higher amounts of NA (neuraminidase) antigen in the development of influenza vaccines

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