Which of the following is not true of the reaction catalyzed by the pyruate dehy

Question

Which of the following is not true of the reaction catalyzed by the pyruate dehydrognase complex? A) Biotin participates in the decarboxylation. B) Both NAD^+ and a flavin nucleotide act as electron carriers. C) The reaction occurs in the mitochondrial matrix. D) The substrate is held by the lipoyl-lysine "swinging arm." E) Two different cofactors containing = SH groups participate. Which of the below is not required for the oxidative decarboxylation of pyruvate to form acetyl-CoA? A) ATP B) CoA-SH C) FAD D) Lipoic acid E) NAD^+ Which combination of cofactors is involved in the conversion of pyruvate to acetyl-CoA? A) Biotin, FAD, and TPP B) Biotin, NAD^+, and FAD C) NAD, biotin, and TPP D) Pyridoxal phosphate, FAD, and lipoic acid E) TPP, lipoic acid, and NAD Which of the following statements about the oxidative decarboxylation of pyruvate in aerobic conditions in animal cells is correct A) One of the products of the reactions of the pyruvate dehydrogenase complex is a thioester of acetate. B) The methyl (-CH_3) group is eliminated as CO_2. C) The process occurs in the cytosolic compartment of the cell. D) The pyruvate dehydrogenase complex uses all of the following as cofactors: NAD^+, lipoic acid, pyridoxal phosphate (PLP), and FAD. E) The reaction is so important to energy production that pyruvate dehydrogenase operates at full speed under all conditions. Glucose labeled with^14C in C-3 and C-4 is completely converted to acetyl-CoA via glycolysis and the pyruvate dehydrogenase complex. What percentage of the acetyl-CoA molecules formed will be label with^14C, and in which position of the acetyl moiety will the^14C label be found? A) 100% of the acetyl-CoA will be labeled at C-1 (carboxyl). B) 100% of the acetyl-CoA will be labeled at C-2. C) 50% of the acetyl-CoA will be labeled, all at C-2 (methyl). D) No label will be found in the acetyl-CoA molecules. E) Not enough information is given to answer this question.

Explanation / Answer

Answer:

1. A). Biotin participates in the dacarboxylation.

Pyruvate dehydrogenase complex (PDC) is a complex of three enzymes that convert pyruvate into acetyl-CoA by a process called pyruvate decarboxylation. It requires FAD and NAD+ as cofactors.

2. A). ATP

3). E).TPP, lipoic acid, and NAD+

4. A). One of the products of the reactions of the pyruvate dehydrogenase complex is a thioester of acetate.

5. D). No label will be found in the acetyl-CoA molecules.

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