Which of the following statements best defines \"the First Pass Effect\"? A. The

Question

Which of the following statements best defines "the First Pass Effect"?

A. The fact that the spleen will filter blood most efficiently the first time the blood is encountered.

B. The term refers to the first time that vasodilators are administered by intramuscular injection.

c. The first time that a chemical that is enhaled enters the lungs, a varying amount diffuses into the blood.

D. The fact that the liver removes a varying amount of a chemical the first time it encounters it from the digestive trac

Explanation / Answer

D. The fact that the liver removes a varying amount of a chemical the first time it encounters it from the digestive tract

The capillary bed of the liver receives nutrient-rich blood through the hepatic portal vein. The blood processing take place in the capillary bed to remove the impurities and toxins, this circulation is called as “hepatic portal circulation.”

All the orally taken drugs pass through the hepatic portal circulation, during which part of the drug will be metabolized by the liver enzymes, this is known as “first pass effect or first-pass metabolism.”

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