There are many actin-binding proteins in cells that can bind to actin and modify
ID: 180291 • Letter: T
Question
There are many actin-binding proteins in cells that can bind to actin and modify its activity. Some proteins such as __________________ bind to actin monomers, sequestering them until needed for filament formation. __________________ proteins bind to the end of actin filaments. The __________________ proteins are important for nucleation of the branched actin structures commonly found in the __________________ of moving cells, whereas __________________ proteins are important for the formation of unbranched actin filaments commonly found in __________________. Proteins belonging to the __________________ family of GTPases regulate changes in the actin cytoskeleton in response to extracellular signals.
word bank:
capping lamellipodia thymosin
integrin ARP formin
filopodia bundling GAP
Rho gelsolin contracting
severing cytochalasin lamin
Explanation / Answer
There are many actin-binding proteins in cells that can bind to actin and modify its activity. Some proteins such as __THYMOSIN________________ bind to actin monomers, sequestering them until needed for filament formation. __CAPPING________________ proteins bind to the end of actin filaments. The ___ARP_______________ proteins are important for nucleation of the branched actin structures commonly found in the __LAMELLIOPODIA________________ of moving cells, whereas __FORMIN________________ proteins are important for the formation of unbranched actin filaments commonly found in ___FILOPODIA_______________. Proteins belonging to the ___Rho_______________ family of GTPases regulate changes in the actin cytoskeleton in response to extracellular signals.
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