Q.23) Answer the mechanism of insulator in eukaryotic gene transcription for blo

Question

Q.23) Answer the mechanism of insulator in eukaryotic gene transcription for blocking the activating signal coming from transcription enhancer to the promoter.

a) Insulator bends DNA to block the activating signal from enhancer

b) Insulator physically prevents mediator complex and general transcription factors binding to promoter DNA

c) Enhancer introduces histone acetylations to form lower order chromatin for transcription activation, but insulator removes acetylations from histone tails to form highly condensed chromosome (heterochromatin)

d) None of the above

Explanation / Answer

b) :insulator physically prevents mediator complex and general transcription factors binding to promoter DNA.

Insulators affects gene expression by mediating intra and inter chromosomal interaction ...Therefore by affecting the intergenic promoters and enhancers activity...involved in the regulation of the gene expression during transcription.

Examples of insulators are : su(HW) insulator found in drosophila ,dCTCF inslator,BEAF insulator.GAGA insulator.etc...

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