C. F3 d. Both A and B 24. What is the function of elF5? a. Encourages associatio
ID: 180282 • Letter: C
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C. F3 d. Both A and B 24. What is the function of elF5? a. Encourages association between 60s ribosome subunit and 48 complex b. Binds to 60S subunit c. Block reassociation with 40S subunit d. Inhibits reassociation with 60s subunit 25. Which of the following is/are the function/s of elF4A a. RNA helicase activity b. Stimulates binding off elF4B and mRNA c. Unwinding activity is GTP dependent d. Unwinds hairpins found in the 3'leaders of eukaryotic mRNA 26. The loss of cap-dependent host protein synthesis in poliovirus infected cells is due to competition by RNA for the limiting amount of a. Viral: p100 b. Bacterial; p100 c. Viral: p200 d. Bacterial; p200 27. In Xenopus oocytes, Maskin binds to elF4E and to CPEB (cytoplasmic polyadenylation element binding protein) Maskin bound to elF4E a. Cannot bind to elF4G b, Inhibits translation c. Can bind to elF4G d. Both A and B 28. Ferritin mRNA translation is subject to by a. Induction; iron b. Induction; magnesium c, Conduction; iron d. Conduction; magnesium 29. Which miRNA blocks translation initiation in human cells? a. let 8 miRNA b, let-7 miRNA c let-6 miRNA d, let-S miRNA 30. When thiamine pyrophosphate (TTP) is abundant: a. Binds aptamer b. Causes conformation shift in mRNA. c. Ties up Shine-Dalgarno in secondary structure d. All of the aboveExplanation / Answer
24. Answer will be OPTION a; eIF5 (Eukaryotic Initiation factor 5) encourages association between 60S ribosome subunit and 48S complex
25. eIF4 is a cap-binding protein and composed of 3 parts: – eIF4E (has actual cap binding activity) – eIF4A – eIF4G. eIF4A Has an RNA helicase activity, thus answer will be the option a.
26. a. viral; p100
27. CPEB–maskin–eIF4E when observed in meiotically arrested oocytes, inhibits translation, thus answer will be option b, inhibits translation
28. Option a; ferritin mRNA translation is iron dependent thus induced by iron
29. Let-7 miRNA is known for translation repression in mammalian cells, translation by inhibiting the function of some translation initiation factor thus answer will be option b.
30. TTP is abundant in all of the above.
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